Alexander Niculescu, III, M.D., Ph.D.

Alexander B. Niculescu, III, M.D., Ph.D. Associate Professor of Psychiatry
Personal Statement	I believe a worthwhile goal for the future is to diagnose and treat patients in an individualized fashion, based on their profile of genes, biomarkers, and quantitative phenotypic data, using low-dose rational polypharmacy to get synergistic benefits and minimize side-effects. Personalized diagnosis and treatment, for every patient, in every doctor’s office!
Education	Graduate School: The Scripps Research Institute, LaJolla, CA Medical School: University of Bucharest Carol Davila School of Medicine Residency: University of California, San Diego Fellowship: University of California, San Diego Board Certifications/Certifications: American Board of Psychiatry and Neurology
Current Academic Interests	Clinical: Personalized medicine in psychiatry, Rational polypharmacology of complex and treatment refractory cases. Research: Genomics and phenomics of neuropsychiatric disorders, Brain and tissue banking, Blood Biomarkers.
Recent Publications	Le-Niculescu H, Kurian SM , Yehyawi N, Dike C, Patel SD, Edenberg HJ, Tsuang MT, Salomon DR, Nurnberger Jr JI, Niculescu AB. Identifying Blood Biomarkers For Mood Disorders Using Convergent Functional Genomics. Molecular Psychiatry 2009; 14(2):156-74. Epub 2008 Feb 26. Patel SD, Le-Niculescu H, Koller DL, Green SD, Lahiri DK, McMahon F, Nurnberger JI, Niculescu AB. Coming to Grips With Complex Disorders: Genetic Risk Prediction in Bipolar Disorder Using Panels of Genes Identified Through Convergent Functional Genomics. American Journal of Medical Genetics Part B (Neuropsychiatric Genetics). 2010. Jun 5;153B(4):850-77. Epub 2010 April 9. Niculescu AB, Schork NJ, Salomon DR. Mindscape: a convergent perspective on life, mind, consciousness and happiness. Journal of Affective Disorders 2010 123(1-3):1-8. Epub 2009 July10.