R. Andrew Chambers, M.D.

R. Andrew Chambers, M.D.
Associate Professor of Psychiatry
Director, Addiction Psychiatry Fellowship Program
Director, Lab for Translational Neuroscience of Dual Diagnosis & Development


Personal Statement 

Our work in the Laboratory for Translational Neuroscience of Dual Diagnosis & Development focuses on exploring causal mechanisms in the brain responsible for extremely high rates of addictions co-morbidity in mental illness. Because both addictions and mental illnesses are in large part neurodevelopmental disorders in which adolescence is a critical transition phase, we are also interested in how the adolescent brain re-wires normally, or abnormally, in mental illnesses as intertwined with the early stages of drug addictions.


Undergraduate: Centre College    

Medical School: Duke University School of Medicine      

Residency: Psychiatry and Neuroscience, Yale University School of
                   Medicine (1996-2000)

Fellowship: Behavioral Neuroscience, Yale University School of
                    Medicine (2000-2002)                                                  

                    Addiction Psychiatry, Indiana University (2010-2012)  

Board Certifications/Certifications:

American Board of Psychiatry and Neurology/General Adult Psychiatry (2001)

American Society of Addiction Medicine/Addiction Medicine (2009) American Board of Psychiatry and Neurology/Addiction Psychiatry (2012)

Current Academic Interests 

Teaching: Medical student education in performing psychiatric examinations; psychiatric resident education in general neuropsychiatry, adolescent neurodevelpment, addictions and dual diagnosis; transformation of psychiatric workforce and  behavioral health systems toward dual diagnosis capability; basic and clinical neuroscience of dual diagnosis disorders, integrated diagnosis and treatment of dual diagnosis disorders

Clinical: Care of adolescents and adults with dual diagnoses (mental illness and substance disorders)

Research: Animal models of mental illness and addictions; behavioral neuroscience; motivation; neural network modeling

Recent Publications 

Chambers, R.A., Sentir, A.M., Contro, S.K., Truitt, W.A., Shekhar, A. (2010) “Cortical-striatal integration of cocaine history and prefrontal dysfunction in animal modeling of dual diagnosis” Biological Psychiatry, 67, 788-792. . Epub 2009 Oct 31. PubMed PMID: 19880093; PubMed Central PMCID: PMC2849854

Chambers, RA , Sentir, AM, Engleman, EA (2010) “Ventral and dorsal striatal dopamine efflux and behavior in rats with simple vs. co-morbid histories of cocaine sensitization and neonatal ventral hippocampal lesions”  Psychopharmacology 212 (1) 73-83. PubMed Central PMCID: PMC2921051.

Chambers, R.A., Bickel, W.K., Potenza, M.N. (2007) “A scale-free systems theory of motivation and addiction” Neuroscience and Biobehavioral Reviews, 31, 1017-1045. Epub 2007 May 3. PubMed PMID: 17574673; PubMed Central PMCID: PMC2150750.
R. Andrew Chambers, M.D.

Neuroscience Research Building
320 West 15th Street
Indianapolis,IN, 46202
(317) 278-1716

Department of Psychiatry | 355 W. 16th St., Suite 4800 | Indianapolis, IN 46202 | Ph: (317) 963-7288 | Fax: (317) 963-7313